Scientific work.
General information.
Scientific activity of the staff of the department
is focused on current issues of modern pediatrics and aimed at:
1
Впровадження
introduction of European and world criteria of developmental medicine, disease prevention at the stage of premorbid background formation
2
Удосконалення
improving the diagnosis and prevention of cardiovascular disorders in newborns, children and adolescents in the Kharkiv region on the basis of scientific research on the stratification of the most influential risk factors for their development in the pediatric population from perinatal to adolescence
3
Поліпшення
improving the prevention of disability, orphanhood, improving the quality of life of children and families, reducing the number and duration of hospitalizations
4
Prevention
prevention of interstitial and eponymous diseases of children in the population of the Kharkiv region
5
Prevention
prevention of disorders of physical and sexual development of children, their quality of life, psychological and social adaptation,
6
Prevention
prevention of the risk of cardiovascular catastrophes in young and adult age, reducing the number of hospitalizations, both in children and later adult life.
Taking into account the main directions of scientific activity of the teaching staff of the department, educational and scientific centers have been created:
I. SC of perinatal and pediatric cardiology:
● perinatal and neonatal cardiology: development of algorithms for monitoring newborns with congenital heart defects in the early neonatal period (developed for the first time in Ukraine);

● population research to determine the normative indicators of the cardiovascular system in children and adolescents in Kharkiv region;

● stratification of cardiovascular risk factors in the pediatric population Kharkiv region (developed for the first time in Ukraine);

● determination of normative indicators of the state of the cardiovascular system of children who does sports (developed for the first time in Ukraine);

● observation and rehabilitation of guch patients. Improving the quality of life of grown-up congenital heart disease patients and their families (developed for the first time in Ukraine).




SCIENTIFIC DIRECTION - CHILDREN'S CARDIOLOGY - Doctor of Medicine, Professor G. Senatorova, Doctor of Medicine, Professor M.Gonchar
● Cardiovascular system in bronchial asthma (G. Senatorova, V. Polyakov, 2013);

● Congenital heart defects in children (M. Gonchar, 2011, A. Boychenko, 2009, D. Khapchenkova, 2016-2022);

● Functional state of the cardiorespiratory complex (G. Senatorova, N. Matsievska, 2011; O. Onikienko, 2016-2021);

● Cardiorespiratory tract remodeling in children with BPD (O. Logvinova, 2015);

● Myocardial remodeling in adolescents with hypertension (M. Gonchar, N. Konovalova, 2015);

● Inflammatory heart disease and arrhythmias and conduction (G.Senatorova, H. Kakabadze, 2011);

● Metabolic disorders and myocardial remodeling in children with cardiomyopathies (K. Sergienko, 2011; I. Sanina, 2012).

SCIENTIFIC DIRECTION - NEONATAL CARDIOLOGY (Doctor of Medicine, Professor M. Gonchar)
● Cardiovascular disorders of the perinatal period: risks and mechanisms of development, early diagnosis, prognosis (A. Boychenko, doctoral dissertation, 2018);

● Cardiovascular disorders in newborns with perinatal injury CNS (T.Teslenko, 2021);

● Critical CHD; Hemodynamically significant open ductus arteriosus in newborns (M. Gonchar, A. Boychenko, 2016);

● Neonatal arrhythmias (Doctor of Medicine, Prof. M. Gonchar);

● Prediction of neonatal arrhythmias is taking into account monitoring daily data ECG and levels of kopeptin, ischemic-modified albumin (Ye. Ivanova, 2021);

● Cardiomyopathies (M. Gonchar, A. Boychenko, G. Senatorova, D. Zatoloka);

Developed 3 patents for a utility model, 1 - for an invention

47 articles have been published in journals of the scientometric database, including 4 articles in the journals SCOPUS and Web of Science.

The materials of the work are presented in reports at 34 scientific-practical and international forums.

II. SC Child Development and Palliative Care (O. Riga)
● increasing the efficiency of diagnosis of developmental disorders;

● development of educational programs in the new field of developmental pediatrics;

● palliative care for children with incurable diseases;

● conducting research in the population;

● counseling of children, parents and specialists;

● study of the validity of the tool for assessing the development of children in the population of Kharkiv region (Ankara, Turkey).
Main directions of implementation:

● Chronic pain syndrome, communications in pediatrics, integrative medicine;

● Development of the field "Development Pediatrics" in conjunction with the European Academy of Pediatrics and the Ukrainian Academy of Pediatrics;

● Membership of international organizations ICPCN;
III. SC of interstitial and eponymous lung diseases in children (Candidate of Medical Sciences, Associate Professor Logvinova Olga):
● Criteria of adverse effects of bronchopulmonary dysplasia (developed for the first time in Ukraine);

● Criteria of predictions the survival of a child with pulmonary hypertension on the background of Bronchopulmonary dysplasia (developed for the first time in Ukraine);

● Prevention of chronic pulmonary heart disease and interstitial lung disease (developed for the first time in Ukraine).

Scientific work

● Developed 4 patent and the utility model, 1 - on the invention;

● Published 63 articles in journals of the scientometric base;

● 2 articles were submitted for publication in SCOPUS journals;

● The materials of the work are presented in reports at 26 scientific-practical and international forums.

Therapeutic work

● Protocols for the treatment of interstitial lung diseases, bronchitis, pneumonia ERS / ATS;

● Developed by: 4 innovations, 2 methodical recommendations Ministry of Health of Ukraine (2014-2015), 57 implementations of the Regional Children's Clinical Hospital.



IV. NSC of endocrinology of development and weight correction in children: (Doctor of Medicine, Prof. T. Chaichenko)
• Multidisciplinary weight correction clinic (developed for the first time in Ukraine);

• Determination of the existence of sensitivity in children with physical disabilities (developed for the first time in Ukraine);

• Population studies to determine ethnic standards of development, lifestyle and nutrition of children (developed for the first time in Ukraine);

• Stratification of cardiometabolic risk factors in children with physical disabilities (developed for the first time in Ukraine);

• Registration as a center for the study of children with sexual differentiation (developed for the first time in Ukraine).
Scientific work:

● Children's obesity - a systematic analysis of predictors of metabolic syndrome – Prof. T. Chaichenko, 2013;

● The value of insulin sensitivity in exercise tolerance and the formation of cardiometabolic risk in obese children - as. prof. O.Rybka, 2018.

Therapeutic work

● Early manifestation of cardiovascular complications in children with type 1 diabetes mellitus - Candidate of Medical Sciences N. Shulga, 2010;

● Early markers of kidney damage in type 1 diabetes in children – Candidate of Medical Sciences K. Muratova, 2014;

● The role of viral infection and nutrition in the development of type 1 diabetes in young children and preschoolers - Candidate of Medical Sciences O. Pomazunovska, 2016 .
Research work carried out at the department:

2014-2016 Stratification of cardiovascular risk factors in the pediatric population in Kharkiv region - the number of examined children - 1178.

2017-2019 Stratification of cardiovascular risk factors of newborns and young children in Kharkiv region - number of examined children -1102.

2020-2022 Stratification of cardio-respiratory risk in children with somatic pathology of Kharkiv region - number of examined children - 20 (continue)

2019-2020 Assessment of the current nutritional status, nutrition-related health problems, nutrition-related health problems of school-aged children in Ukraine » - priority funding T. Chaichenko, M. Gonchar.

Perspective areas
Perspective areas of research in the field of perinatal and pediatric cardiology:
1
Perinatal and neonatal cardiology.
Stratification of cardiovascular risk factors in the pediatric population of Kharkiv region (developed for the first time in Ukraine);
2
Perinatal and neonatal cardiology.
Perinatal and neonatal cardiology. Creation of algorithms for monitoring newborns with congenital heart defects in the early neonatal period (developed for the first time in Ukraine);

3
Determination
Determination of normative indicators of the state of the cardiovascular system in children who does sport (developed for the first time in Ukraine).
4
Monitoring and rehabilitation
Monitoring and rehabilitation of guch patients. Improving the quality of life of grown-up congenital heart disease patients and their families (developed for the first time in Ukraine).
Dissertation works performed at the department
● Early diagnosis and prediction of arterial hypertension in children after surgical correction of aortic coarctation. Applicant for the degree «Doctor of Philosophy» - D. Khapchenkova, 2018-2022.

● Insulin sensitivity options in children with hyperlipidemia and cardiovascular risk factors of their parents. Applicant for the degree «Doctor of Philosophy» - M.Kharkova, 2018-2022.

● Optimization of diagnosis and approaches to the treatment of chronic pain in children with paralytic syndromes. Applicant for the degree of «Doctor of Philosophy» – N. Orlova, 2018-2022.

● Optimization of diagnosis and identification of risk factors for cardiovascular disease in children with juvenile idiopathic arthritis. Applicant for the degree «Doctor of Philosophy» - M. Prykhodko, 2019-2023.

● Optimization of diagnosis and correction of hypovitaminosis D in children with paralytic syndromes during the COVID-19.

Applicant for the degree «Doctor of Philosophy» - О. Mikhailova, 2020-2024

Dissertation works performed at the department
● Clinical-instrumental and biochemical comparisons of the cardiovascular system state of children with congenital heart defects. Applicant for the degree "Doctor of Medical Sciences "- M. Gonchar, 2011.

● Chronic kidney disease in children: the concept of development, progression and formation of cardiovascular complications. Applicant for the degree "Doctor of Medical Sciences "- N. Makeeva, 2011.

● Obesity in children - a systematic analysis of predictors of metabolic syndrome. Applicant for the degree "Doctor of Medical Sciences" – T. Chaichenko, 2012

● Diagnosis and prediction of hemodynamic disorders in newborns. Applicant for the degree "Doctor of Medical Sciences"- O. Riga, 2013

● Bronchopulmonary dysplasia in children: risk of development, prediction of consequences and their prevention. Applicant for the degree "Doctor of Medical Sciences "- O. Logvinova, 2016

● "Cardiovascular disorders of the perinatal period: development risk stratification, diagnosis and prognosis". Applicant for the degree "Doctor of Medical Sciences "- A. Boychenko, 2018

● Functional condition of the cardiorespiratory complex of boys 10-11 years old who do sport. Applicant for the degree «Candidate of Medical Sciences» - O. Onikienko, 2021

● Cardiovascular disorders in newborns with convulsive syndrome: diagnosis and prediction. Applicant for the degree "Candidate of Medical Sciences" – T. Teslenko, 2021

● Prediction and prevention of neonatal arrhythmias taking into account the data of daily ECG monitoring and levels of kopeptin, ischemic-modified albumin. Applicant for the degree «Doctor of Philosophy» - Ye. Ivanova, 2016–2020;

● Prognostic value of Tyr113His polymorphism in mEPOX1 gene and blood magnesium in children with acute obstructive bronchitis. Applicant for the degree «Doctor of Philosophy» - M. Strelkova, 2016–2020.
Resume
For the last 5 years the staff and applicants of the department have defended 5 candidate dissertations and 2 doctoral dissertations. Currently, 2 candidate dissertations and 6 works for the degree of Doctor of Philosophy are being completed. Received 18 utility model patents and more than 400 implementation acts. The department has published more than 500 articles and about 600 abstracts of reports at scientific forums of various levels.
International and industry recognition of the department is represented by the results of research, which are implemented: reports - 1 15 forums [1] (30 of them international), 121 articles (10 of them international), 150 theses (21 of them international), utility model patent - 6, invention patent -1, certificate of authorship - 1.

I will be grateful if you write your achievements, which will be covered on the website of KhNMU


Every year, employees receive grants for study and internships abroad: Austria (Open Medical Institute, University Clinic of Vienna), Great Britain (University of Cambridge, University of Cardiff); Spain (University of Barcelona Clinic); Kingdom of the Netherlands (Hagia Sophia Clinic, Erasmus University Rotterdam); Italy (children's palliative clinic); Germany (Children's Hospital of St. Augustine "Asclepius").

During the current 5 years, the staff of the Department of Pediatrics № 1 and neonatology took part in international congresses, conferences and congresses: Berlin, Ulm, Frankfurt, Munich (Germany), Athens (Greece), Nice, Paris (France), Stockholm (Sweden), Barcelona (Spain), Glasgow, London (Great Britain), Porto (Portugal), Rotterdam (Holland) and others.
Membership in international organizations


• HealthProm, United Kingdom

• The European Society of Cardiology

• Acute cardiovascular care association (ACCA).

• Education in Palliative and End-of-Life Care

• European respiratory society

• European Association of Pediatric Endocrinologists (ESPE)

• ESPE obesity working group

• Ukrainian-German Medical Association

• The Association for European Pediatric and Congenital Cardiology

• European Academy of Pediatrics

• Acute cardiovascular care association

• European Academy of Allergy and Clinical Immunology

• American Academy Pediatrics

• Israeli Doctors Association

Clinical internships of the department staff
Long-term programs:

• Children's Hospice Rainbows, London, Great Britain (Prof. O. Riga), 2016

• AKN University Clinic, Vienna, Austria (Prof. T. Chaichenko), 2016

• Hagia Sophia Clinic, Erasmus University, Rotterdam, Kingdom of the Netherlands (Prof. O.Riga), 2014

• Cardiff University University Clinic, Cardiff, Great Britain (Prof. T. Chaichenko), 2010

• Mevlana Exchange program for Academic stuff, Antalya, Turkey (Prof. T. Chaichenko), 2016

• Alin Rehabilitation Center, Israel, 2015 (Prof. O. Riga)